“Mens Sana in Cute Sana”—A State of the Art of Mutual Etiopathogenetic Influence and Relevant Pathophysiological Pathways between Skin and Mental Disorders: An Integrated Approach to Contemporary Psychopathological Scenarios

The negative socioeconomic impact of mental health disorders and skin diseases has increased in part due to the conflict between Russia Ukraine, which been a fertile ground for emergence psychopathologies. It is firmly established that there direct thread etiopathogenetic communication neuropsychiatric disorders, literature tried reveal pathophysiological mechanisms governing such bidirectionality. This paper discusses this complex network molecular pathways are targeted by conventional biological pharmacological agents appear two pathological spheres previously seemed have little connection. discussion supplemented with review, from clinical viewpoint, regarding skin–brain We focus on post-traumatic stress disorder (PTSD), can be considered all intents purposes systemic inflammatory disease also affects skin. A brief overview provided diagnostic–therapeutic follow-up potential oxidative markers potentially involved treated. aim clarify how these may useful defining different stress-coping strategies thus individual phenotypes sensitivity/resistance order promote personalized medicine field psychodermatology.